Polynucleotides
in London.

No, polynucleotides and dermal fillers belong to different categories of aesthetic treatment with different goals. Filler is hyaluronic acid gel designed to add volume by physically occupying space under the skin. Polynucleotides are purified DNA fragments designed to act on cellular receptors involved in tissue repair, supporting your own skin's regenerative response over weeks. They are not interchangeable. Filler is right when the goal is volume restoration in a specific area, such as lips, cheeks or chin. Polynucleotides may be more appropriate when the goal is skin quality, hydration, or under-eye texture. We assess your specific concern at consultation and recommend the right category honestly, including saying no if neither is the right fit.

The most studied polynucleotide source in clinical aesthetics is purified salmon DNA fragments. The molecules are isolated, purified to clinical-grade standards, and the genetic information is removed during processing. What remains is a regenerative scaffold of nucleotides, not viable DNA, and it cannot transfer genetic material. Nucleofill, the product range we use, sources its polynucleotides this way and is CE-marked for clinical use in the EU. Salmon DNA has been chosen because its molecular structure is well-tolerated by human cells in published research. Patients with confirmed fish allergy or hypersensitivity should not have this treatment, and we screen for this in every consultation. If you have a known allergy, polynucleotides are not the right option for you.

Three sessions, spaced three to four weeks apart, is the standard treatment course supported by current clinical evidence for polynucleotide-class injectables. The interval is designed to align with the dermal collagen synthesis cycle, allowing each session to build on the response from the last. After completion, most clients return for maintenance once or twice per year, depending on individual response and skin goals. A single session can show some early change but is not the recommended protocol. We sell Nucleofill as a Course of 3 from £540 specifically because evidence supports the full course over single sessions. Individual results vary, and we discuss realistic expectations during your treatment.

Most clients begin noticing gradual changes around weeks 2 to 4 after the first session, with the strongest effect typically reported between weeks 8 and 12 after completing the full course. Polynucleotides work over time rather than immediately, because they are designed to stimulate your skin's own regenerative response rather than fill or paralyse tissue. The published evidence for polynucleotide-class injectables describes outcomes developing across the dermal layer over weeks, not days. The first sign for most clients is improved hydration and a calmer skin tone, followed by texture refinement and improved firmness as the course progresses. Individual results vary based on age, skin condition, lifestyle and Fitzpatrick type, and we discuss realistic expectations honestly at consultation.

Nucleofill Eyes is a polynucleotide product specifically formulated for the delicate under-eye area, targeting crepey texture, fine lines, and the tired-eye appearance caused by skin quality changes rather than volume loss. It is not a volume-replacement filler. The under-eye area is one of the better-studied applications for polynucleotide injectables, and published research on this region suggests improvements in skin elasticity and barrier function over the standard course. If your under-eye concern is hollowing or volume loss, a different category of treatment such as filler may be more appropriate. If your concern is dark circles caused by genetic vascular pigmentation rather than texture or hydration, no aesthetic injectable can change that, and we will tell you so honestly. Our clinical team will give you an evidence-based assessment at consultation.

Brand-specific clinical evidence for polynucleotide injectables in hair regeneration is currently limited, and we will be honest about that. The polynucleotide category has emerging research interest for scalp application, particularly for early-stage androgenetic thinning, post-pregnancy or stress-related shedding, and weakening hairlines where the follicles are still present but underperforming. Nucleofill Hair is designed to support the scalp environment and may improve the conditions in which existing follicles function. It is not a hair transplant, and it will not regrow hair from follicles that have already been lost permanently. Candidates with active early-stage thinning who still have visible vellus or miniaturised hair tend to respond better than those with completely smooth bald patches. We assess realistic expectations at consultation and will say if this is not the right fit.

Most clients experience small raised injection bumps that resolve within 4 to 24 hours, occasional pinpoint redness, and the possibility of light bruising at injection sites. Most return to work or normal activities the same day. We recommend avoiding strenuous exercise, alcohol, hot showers and sauna for 24 hours after treatment to allow injection sites to settle. Makeup can be applied gently the following day. Significant swelling, persistent pain, asymmetry, or signs of infection are not expected; if you experience any of these, contact us via WhatsApp immediately. For darker skin tones (Fitzpatrick IV to VI), we use conservative injection technique and confirm healing response at follow-up to minimise any post-inflammatory hyperpigmentation risk, which the literature identifies as the key parameter to manage in pigmented skin.

No, we do not deliver polynucleotide treatments during pregnancy or breastfeeding. This is a precautionary medical position consistent with standard UK aesthetic practice. While no specific clinical evidence indicates harm from polynucleotide injectables in pregnancy, there is also no published safety data confirming they are risk-free, and we will not treat without that confirmation. We will ask about pregnancy and breastfeeding status at every consultation. If you are planning a pregnancy or actively trying to conceive, we recommend completing any course of treatment before that point. We are happy to discuss topical skin care alternatives appropriate for pregnancy and breastfeeding during a consultation, and to schedule a treatment course for after you have finished breastfeeding.

All polynucleotide injectable treatments at Melatone are delivered by Arman Zaki, GMC-registered Physician Associate , who founded the clinic and trained in the NHS, or by a credentialled member of our clinical team following an in-person clinical assessment. Polynucleotide injectables are delivered by Arman and Vicki Lefeuve (Aesthetic Practitioner, regenerative aesthetics trained); the role map for polynucleotides is Arman as the lead clinician with Vicki as the second-chair injector. Every patient is reviewed by a clinician before their first session, regardless of which booking pathway they use. The clinic operates under the supervision of Arman Zaki as Founder and Lead Clinician. We do not subcontract injectable work to external practitioners. You will know who is treating you before any needle touches your skin.

For most clients, you can book Nucleofill Eyes, Strong, or Hair directly on Treatwell without a separate consultation, because the clinical assessment is built into your first appointment. The clinician will review your medical history, skin type, current concerns and goals, take photos for your file, and confirm the product and technique before any injection. If you would prefer to confirm which product is right for you before booking, you can either message us on WhatsApp for an informal pre-booking question, or book a 20-minute paid consultation on Treatwell (£30, redeemed against your first treatment if you proceed). We recommend the formal consultation route if you have a complex medical history, are taking medication that affects healing, or are weighing polynucleotides against other treatment categories.